Kaepernick throws 4 picks, Cardinals rout 49ers 47-7

Arizona Cardinals defensive end Calais Campbell (93) signals safety during the second half of an NFL football game against the San Francisco 49ers, Sunday, Sept. 27, 2015, in Glendale, Ariz. (AP Photo/Ross D. Franklin)

GLENDALE, Ariz. (AP) — Carson Palmer threw for 311 yards and Arizona returned two of Colin Kaepernick’s first four passes for touchdowns and the Cardinals romped past the San Francisco 49ers 47-7 on Sunday.

Larry Fitzgerald caught nine passes for 134 yards and two touchdowns and Chris Johnson rushed for 110 yards and two scores for the Cardinals (3-0), who won at Chicago 48-23 last week.

It’s the first time the franchise has had two 40-point victories in a row since 1969 and its largest margin of victory since a 44-0 win over Houston in 1970.

Kaepernick threw a career-worst four interceptions, two by Tyrann Mathieu, and finished 9 for 19 for 67 yards.

Justin Bethel returned the first one 21 yards for a touchdown and Mathieu ran untouched 33 yards for another score.

Kaepernick had a 12-yard TD run for San Francisco (1-2).

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